Patent: Injectable, bioadhesive cryogel scaffolds for biomedical uses

Inventors: Devyesh Rana, Sidi A. Bencherif, Nasim Annabi

Abstract: Disclosed herein are functionalized dopamine derivatives comprising an optionally substituted acrylic acid moiety and optionally a polyethylene glycol linking moiety. The functionalized dopamine derivatives are useful in cryogel formulations to improve the adhesivity of the cryogel, while preventing undesirable oxidation typically associated with dopamine-containing hydrogels and cryogels. Properties such as cryogel adhesivity, pore size, and interconnectivity are tunable features. Also provided herein are methods of treating a wound or promoting tissue regeneration with a cryogel of the invention or a formulation comprising such a cryogel.

Full Patent Link: https://patents.google.com/patent/US11850325B2/en